Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sci Transl Med. 2013 Mar 13;5(176):176ps4. doi: 10.1126/scitranslmed.3003997.
Acellular biomaterials can stimulate the local environment to repair tissues without the regulatory and scientific challenges of cell-based therapies. A greater understanding of the mechanisms of such endogenous tissue repair is furthering the design and application of these biomaterials. We discuss recent progress in acellular materials for tissue repair, using cartilage and cardiac tissues as examples of applications with substantial intrinsic hurdles, but where human translation is now occurring.
细胞外生物材料可以刺激局部环境来修复组织,而没有细胞治疗的监管和科学挑战。对这种内源性组织修复机制的更深入了解进一步推动了这些生物材料的设计和应用。我们讨论了用于组织修复的细胞外材料的最新进展,以软骨和心脏组织为例,这些应用具有很大的内在障碍,但现在正在进行人体转化。