SLC20 和 SLC34 家族的磷酸盐转运蛋白。

Phosphate transporters of the SLC20 and SLC34 families.

机构信息

Institute of Physiology and Zurich Center for Integrated Human Physiology, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland.

出版信息

Mol Aspects Med. 2013 Apr-Jun;34(2-3):386-95. doi: 10.1016/j.mam.2012.07.007.

DOI:10.1016/j.mam.2012.07.007

PMID:23506879

Abstract

Transport of inorganic phosphate (Pi) across the plasma membrane is essential for normal cellular function. Members of two families of SLC proteins (SLC20 and SLC34) act as Na(+)-dependent, secondary-active cotransporters to transport Pi across cell membranes. The SLC34 proteins are expressed in specific organs important for Pi homeostasis: NaPi-IIa (SLC34A1) and NaPi-IIc (SLC34A3) fulfill essential roles in Pi reabsorption in the kidney proximal tubule and NaPi-IIb (SLC34A2) mediates Pi absorption in the gut. The SLC20 proteins, PiT-1 (SLC20A1), PiT-2 (SLC20A2) are expressed ubiquitously in all tissues and although generally considered as "housekeeping" transport proteins, the discovery of tissue-specific activity, regulatory pathways and gene-related pathophysiologies, is redefining their importance. This review summarizes our current knowledge of SLC20 and SLC34 proteins in terms of their basic molecular characteristics, physiological roles, known pathophysiology and pharmacology.

摘要

无机磷酸盐（Pi）穿过质膜的转运对于正常的细胞功能至关重要。两类 SLC 蛋白家族（SLC20 和 SLC34）的成员作为 Na(+)-依赖性、继发性主动共转运体，将 Pi 穿过细胞膜进行转运。SLC34 蛋白在 Pi 稳态的重要特定器官中表达：NaPi-IIa（SLC34A1）和 NaPi-IIc（SLC34A3）在肾脏近端小管的 Pi 重吸收中发挥重要作用，而 NaPi-IIb（SLC34A2）介导肠道中的 Pi 吸收。SLC20 蛋白，PiT-1（SLC20A1）和 PiT-2（SLC20A2）在所有组织中广泛表达，尽管通常被认为是“管家”转运蛋白，但对其组织特异性活性、调节途径和基因相关病理生理学的发现，正在重新定义它们的重要性。这篇综述总结了我们目前对 SLC20 和 SLC34 蛋白的基本分子特征、生理作用、已知病理生理学和药理学的了解。