aDepartment of Pediatrics, The Children's Hospital of Philadelphia bDepartment of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA cDepartment of Surgery, Emory Transplant Center, Emory University dDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
Curr Opin Nephrol Hypertens. 2013 May;22(3):336-43. doi: 10.1097/MNH.0b013e32835fe55b.
Kidney transplantation remains the optimal treatment for children with end-stage renal disease; yet, in the United States, profound differences in access to transplant persist, with black children experiencing significantly reduced access to transplant compared with white children. The reasons for these disparities remain poorly understood. Several recent studies provide new insights into the interplay of socioeconomic status, racial/ethnic disparities and access to pediatric kidney transplantation.
New evidence suggests that disparities are more pronounced in access to living vs. deceased donors. National allocation policies have mitigated racial differences in pediatric deceased donor kidney transplant (DDKT) access after waitlisting. However, disparities in access to DDKT are stark for minority emerging adults, who lose pediatric priority allocation. Although absence of health insurance poses an important barrier to transplant, even after adjustment for insurance status and neighborhood poverty, disparities persist. Differential access to care and unjust social structures are posited as important modifiable barriers to achieving equity in pediatric transplant access.
Future approaches to overcome disparities in pediatric kidney transplant access must focus on the continuum of the transplant process, including equitable health care access. Public health advocacy efforts to promote national policies that address disparate multilevel socioeconomic factors are essential.
目的综述:肾移植仍然是治疗终末期肾病儿童的最佳方法;然而,在美国,儿童接受肾移植的机会存在显著差异,与白人儿童相比,黑人儿童接受肾移植的机会明显减少。造成这些差异的原因仍知之甚少。最近的几项研究为理解社会经济地位、种族/民族差异和儿童肾移植机会之间的相互作用提供了新的见解。
最近的发现:新的证据表明,在活体供体和已故供体之间,获得供体的机会差异更为明显。国家分配政策缓解了等待名单上的儿童已故供体肾移植(DDKT)获得的种族差异。然而,对于少数族裔的成年初显期患者来说,DDKT 的获得机会仍然存在明显的差异,他们失去了儿童优先分配的资格。尽管没有健康保险是移植的一个重要障碍,但即使在调整了保险状况和社区贫困状况后,差异仍然存在。护理机会的差异和不公正的社会结构被认为是实现儿童移植机会公平的重要可改变的障碍。
总结:未来克服儿童肾移植机会差异的方法必须侧重于移植过程的连续性,包括公平的医疗保健机会。公共卫生宣传工作对于促进解决不同层次社会经济因素的国家政策至关重要。