Department of Chemistry, Lakehead University, 955 Oliver Road, Thunder Bay, Ontario P7B 5E1, Canada.
Chem Soc Rev. 2013 Jun 21;42(12):5425-38. doi: 10.1039/c3cs35518g.
A growing variety of sensors have increasingly significant impacts on everyday life. Key issues to take into consideration toward the integration of biosensing platforms include the demand for minimal costs and the potential for real time monitoring, particularly for point-of-care applications where simplicity must also be considered. In light of these developmental factors, electrochemical approaches are the most promising candidate technologies due to their simplicity, high sensitivity and specificity. The primary focus of this review is to highlight the utility of nanomaterials, which are currently being studied for in vivo and in vitro medical applications as robust and tunable diagnostic and therapeutic platforms. Highly sensitive and precise nanomaterials based biosensors have opened up the possibility of creating novel technologies for the early-stage detection and diagnosis of disease related biomarkers. The attractive properties of nanomaterials have paved the way for the fabrication of a wide range of electrochemical sensors that exhibit improved analytical capacities. This review aims to provide insights into nanomaterials based electrochemical sensors and to illustrate their benefits in various key biomedical applications. This emerging discipline, at the interface of chemistry and the life sciences, offers a broad palette of opportunities for researchers with interests that encompass nanomaterials synthesis, supramolecular chemistry, controllable drug delivery and targeted theranostics in biology and medicine.
越来越多的传感器对日常生活产生了越来越大的影响。在生物传感平台的集成中需要考虑的关键问题包括对低成本的需求和实时监测的潜力,特别是在即时护理应用中,还必须考虑到简单性。鉴于这些发展因素,由于其简单性、高灵敏度和特异性,电化学方法是最有前途的候选技术。本篇综述的主要重点是强调纳米材料的实用性,目前正在研究纳米材料作为用于体内和体外医学应用的稳健和可调谐诊断和治疗平台。基于高灵敏度和高精度的纳米材料的生物传感器为开发用于早期检测和诊断与疾病相关生物标志物的新技术开辟了可能性。纳米材料的诱人特性为制造具有改进分析能力的各种电化学传感器铺平了道路。本篇综述旨在深入了解基于纳米材料的电化学传感器,并说明它们在各种关键生物医学应用中的优势。这一新兴学科处于化学和生命科学的交叉点,为对纳米材料合成、超分子化学、可控药物输送和生物学和医学中的靶向治疗学感兴趣的研究人员提供了广泛的机会。