血浆甲状旁腺激素与代谢综合征及心血管疾病风险的关联。
Association of plasma parathyroid hormone with metabolic syndrome and risk for cardiovascular disease.
机构信息
Division of Endocrinology, Metabolism and Nutrition, Department of Medicine, Rutgers University-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
出版信息
Endocr Pract. 2013 Jul-Aug;19(4):712-7. doi: 10.4158/EP12440.RA.
OBJECTIVE
To review the current literature investigating the association of plasma parathyroid hormone (PTH) with the prevalence of metabolic syndrome and the risk for cardiovascular disease (CVD).
METHODS
We conducted a search of PubMed and Medline database using the terms hyperparathyroidism, metabolic syndrome, hypertension, hyperlipidemia, hyperglycemia, and CVD. We reviewed relevant studies from 2004 to 2012.
RESULTS
The current literature assessing the association of plasma PTH levels with metabolic syndrome and CVD is inconsistent; however, positive associations among hyperparathyroidism, metabolic syndrome, and CVD were found in a majority of the studies. The differences in the study populations may partly explain the mixed results.
CONCLUSION
In the general population, a high serum PTH level predisposes patients to CVD mortality. Further research is needed to determine the role of PTH in the etiology of metabolic syndrome and CVD.
目的
综述目前关于血浆甲状旁腺激素（PTH）与代谢综合征患病率及心血管疾病（CVD）风险之间关联的文献。
方法
我们使用“甲状旁腺功能亢进、代谢综合征、高血压、血脂异常、高血糖和 CVD”等术语，在 PubMed 和 Medline 数据库中进行了检索。我们回顾了 2004 年至 2012 年的相关研究。
结果
评估血浆 PTH 水平与代谢综合征和 CVD 之间关联的现有文献并不一致；然而，大多数研究发现甲状旁腺功能亢进、代谢综合征和 CVD 之间存在正相关关系。研究人群的差异可能部分解释了结果的不一致。
结论
在一般人群中，高血清 PTH 水平使患者易患 CVD 死亡。需要进一步研究以确定 PTH 在代谢综合征和 CVD 的病因学中的作用。
Zotero 插件