B细胞在心力衰竭中的作用。
The role of B-cells in heart failure.
作者信息
Cordero-Reyes Andrea M, Youker Keith A, Torre-Amione Guillermo
机构信息
Methodist DeBakey Heart & Vascular Center, The Methodist Hospital, Houston, Texas, USA.
出版信息
Methodist Debakey Cardiovasc J. 2013 Jan-Mar;9(1):15-9. doi: 10.14797/mdcj-9-1-15.
Abstract
Heart failure is a complex disease that has great impact on morbidity and mortality in the general population. No recent therapies have proven to be effective; however, the discovery of new potential pathophysiological mechanisms involved in heart failure expression and progression could offer novel therapeutic strategies. A number of studies have shown that the immune system may be a central mediator in the development and progression of heart failure, and here we describe how the B-cell and B-cell-mediated pathways play specific roles in the heart failure state. Therapies aimed at B-cells, either blocking antibody production or inactivating B-cell function, may suggest potential new treatment strategies.
摘要
心力衰竭是一种复杂的疾病，对普通人群的发病率和死亡率有重大影响。近期尚无治疗方法被证明有效；然而，发现参与心力衰竭发生和进展的新的潜在病理生理机制可能会提供新的治疗策略。多项研究表明，免疫系统可能是心力衰竭发生和进展的核心介质，在此我们描述B细胞和B细胞介导的途径在心力衰竭状态中如何发挥特定作用。针对B细胞的疗法，无论是阻断抗体产生还是使B细胞功能失活，都可能提示潜在的新治疗策略。
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