自由基 SAM/钴胺甲基化的机制：一个不断发展的工作假说。
The mechanisms of radical SAM/cobalamin methylations: an evolving working hypothesis.
机构信息
Biomolecular Sciences Research Complex, EastChem School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, UK.
出版信息
Chembiochem. 2013 Apr 15;14(6):675-7. doi: 10.1002/cbic.201200762. Epub 2013 Mar 25.
ALL ABOUT ME
Pierre and co-workers have revealed mechanistic details of a tryptophan methyltransferase (TsrM) involved in the biosynthesis of the thiopeptide antibiotic, thiostrepton. Utilising cobalamin and a [4Fe-4S] cluster to generate 2-methyltryptophan from tryptophan, a key difference between this enzyme and other radical SAM methyltransferases is that the reaction is not initiated by a single-electron reduction of SAM to generate 5'-dA⋅.
我的全部信息
Pierre 及其同事揭示了参与硫肽类抗生素硫链丝菌素生物合成的色氨酸甲基转移酶（TsrM）的机制细节。该酶利用钴胺素和[4Fe-4S]簇将色氨酸转化为 2-甲基色氨酸，与其他自由基 SAM 甲基转移酶的一个关键区别是，该反应不是通过 SAM 的单电子还原生成 5'-dA⋅来引发的。
Zotero 插件