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蓝藻:药物发现的潜在候选者。

Cyanobacteria: potential candidates for drug discovery.

机构信息

Algology Section, CSIR-National Botanical Research Institute, Lucknow, 226001, Uttar Pradesh, India.

出版信息

Antonie Van Leeuwenhoek. 2013 May;103(5):947-61. doi: 10.1007/s10482-013-9898-0. Epub 2013 Mar 27.

Abstract

Cyanobacteria are a rich source of vast array of bioactive molecules including toxins with wide pharmaceutical importance. They show varied bioactivities like antitumor, antiviral, antibacterial, antifungal, antimalarial, antimycotics, antiproliferative, cytotoxicity, immunosuppressive agents and multi-drug resistance reversers. A number of techniques are now developed and standardized for the extraction, isolation, detection and purification of cyanobacterial bioactive molecules. Some of the compounds are showing interesting results and have successfully reached to phase II and phase III of clinical trials. These compounds also serve as lead compounds for the development of synthetic analogues with improved bioactivity. Cyanobacterial bioactive molecules hold a bright and promising future in scientific research and great opportunity for drug discovery. This review mainly focuses on anticancerous, antiviral and antibacterial compounds from cyanobacteria; their clinical status; extraction and detection techniques.

摘要

蓝藻是各种具有广泛药物重要性的生物活性分子(包括毒素)的丰富来源。它们具有多种生物活性,如抗肿瘤、抗病毒、抗菌、抗真菌、抗疟原虫、抗真菌、抗增殖、细胞毒性、免疫抑制剂和多药耐药逆转剂。现在已经开发和标准化了许多技术用于提取、分离、检测和纯化蓝藻生物活性分子。一些化合物显示出有趣的结果,并已成功进入临床试验的第二阶段和第三阶段。这些化合物也可作为开发具有改善生物活性的合成类似物的先导化合物。蓝藻生物活性分子在科学研究中有着光明和充满希望的未来,并为药物发现提供了巨大的机会。本文主要集中讨论蓝藻的抗癌、抗病毒和抗菌化合物;它们的临床状况;提取和检测技术。

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