羟氯喹通过抑制自噬优先诱导 CD45RO+效应 T 细胞凋亡：一种治疗性调节 T 细胞的可能机制。
Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: a possible mechanism for therapeutic modulation of T cells.
出版信息
J Allergy Clin Immunol. 2013 May;131(5):1443-6.e1. doi: 10.1016/j.jaci.2013.02.026. Epub 2013 Mar 28.
Abstract
Although hydroxychloroquine is used for treatment of numerous autoimmune disorders the mechanism is unclear. We here demonstrate that hydroxychloroquine preferentially induces apoptosis of CD45RO+ memory and effector T cells by inhibiting the survival pathway of autophagy.
摘要
尽管羟氯喹被用于治疗许多自身免疫性疾病，但具体机制尚不清楚。我们在此证明，羟氯喹通过抑制自噬的生存途径，优先诱导 CD45RO+记忆性和效应 T 细胞凋亡。
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