Genotoxic assessment of carbon nanotubes. - Suppr | 超能文献

Genotoxic assessment of carbon nanotubes.

作者信息

Nešković Olivera, Joksić Gordana, Valenta-Šobot Ana, Cvetićanin Jelena, Trpkov Djordje, Leskovac Andreja, Petrović Sandra

机构信息

Institute of Nuclear Sciences Vinča, University of Belgrade, Belgrade, Serbia.

出版信息

Methods Mol Biol. 2013;991:315-23. doi: 10.1007/978-1-62703-336-7_29.

DOI:10.1007/978-1-62703-336-7_29

Abstract

Carbon nanotubes are unique one-dimensional macromolecules with promising application in biology and medicine. Since their toxicity is still under debate, here we describe an investigation of genotoxic properties of purified single-walled carbon nanotubes (SWCNT), multiwall carbon nanotubes (MWCNT), and amide-functionalized purified SWCNT. We used two different cell systems: cultured human lymphocytes where we employed cytokinesis-block micronucleus test and human fibroblasts where we investigate the induction of DNA double-strand breaks (DSBs) employing H2AX phosphorylation assay.

摘要

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