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老年髋部骨折患者早期功能预后能否预测 1 年死亡率?

Does early functional outcome predict 1-year mortality in elderly patients with hip fracture?

机构信息

Clinic for Physical Medicine and Rehabilitation, Clinical Center Serbia, Faculty of Medicine, University of Belgrade, Pasterova 2, 11000, Belgrade, Serbia.

出版信息

Clin Orthop Relat Res. 2013 Aug;471(8):2703-10. doi: 10.1007/s11999-013-2955-1. Epub 2013 Apr 2.

Abstract

BACKGROUND

Hip fractures in the elderly are followed by considerable risk of functional decline and mortality.

QUESTIONS/PURPOSES: The purposes of this study were to (1) explore predictive factors of functional level at discharge, (2) evaluate 1-year mortality after hip fracture compared with that of the general population, and (3) evaluate the affect of early functional outcome on 1-year mortality in patients operated on for hip fractures.

METHODS

A total of 228 consecutive patients (average age, 77.6 ± 7.4 years) with hip fractures who met the inclusion criteria were enrolled in an open, prospective, observational cohort study. Functional level at discharge was measured with the motor Functional Independence Measure (FIM) score, which is the most widely accepted functional assessment measure in use in the rehabilitation community. Mortality rates in the study population were calculated in absolute numbers and as the standardized mortality ratio. Multivariate regression analysis was used to explore predictive factors for motor FIM score at discharge and for 1-year mortality adjusted for important baseline variables.

RESULTS

Age, health status, cognitive level, preinjury functional level, and pressure sores after hip fracture surgery were independently related to lower discharge motor FIM scores. At 1-year followup, 57 patients (25%; 43 women and 14 men) had died. The 1-year hip fracture mortality rate compared with that of the general population was 31% in our population versus 7% for men and 23% in our population versus 5% for women 65 years or older. The 1-year standardized mortality rate was 341.3 (95% CI, 162.5-520.1) for men and 301.6 (95% CI, 212.4-391.8) for women, respectively. The all-cause mortality rate observed in this group was higher in all age groups and in both sexes when compared with the all-cause age-adjusted mortality of the general population. Motor FIM score at discharge was the only independent predictor of 1-year mortality after hip fracture.

CONCLUSIONS

Functional level at discharge is the main determinant of long-term mortality in patients with hip fracture. Motor FIM score at discharge is a reliable predictor of mortality and can be recommended for clinical use.

摘要

背景

老年人髋部骨折后功能下降和死亡的风险相当大。

问题/目的:本研究的目的是:(1)探讨出院时功能水平的预测因素,(2)评估髋部骨折患者与普通人群相比的 1 年死亡率,(3)评估髋部骨折患者早期功能结局对 1 年死亡率的影响。

方法

共纳入 228 例符合纳入标准的髋部骨折连续患者(平均年龄 77.6±7.4 岁),进行一项开放、前瞻性、观察性队列研究。出院时的功能水平通过运动功能独立性测量(FIM)评分来衡量,这是康复界最广泛使用的功能评估方法。研究人群的死亡率以绝对值和标准化死亡率表示。多变量回归分析用于探索与出院时运动 FIM 评分和 1 年死亡率相关的预测因素,这些因素在调整了重要基线变量后进行了分析。

结果

年龄、健康状况、认知水平、受伤前功能水平和髋部骨折手术后压疮是与出院时运动 FIM 评分较低相关的独立因素。在 1 年随访时,57 例患者(25%;43 名女性和 14 名男性)死亡。与普通人群相比,我们人群中的 1 年髋部骨折死亡率为 31%,男性为 7%,我们人群中的 1 年女性标准化死亡率为 23%,女性为 5%,年龄在 65 岁及以上。男性的 1 年标准化死亡率为 341.3(95%CI,162.5-520.1),女性为 301.6(95%CI,212.4-391.8)。与普通人群的全因年龄调整死亡率相比,该组的全因死亡率在所有年龄组和所有性别中均较高。出院时的 FIM 运动评分是髋部骨折后 1 年死亡的唯一独立预测因素。

结论

髋部骨折患者出院时的功能水平是长期死亡率的主要决定因素。出院时的 FIM 运动评分是死亡率的可靠预测指标,可推荐用于临床使用。

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