2型糖尿病中肿瘤坏死因子和淋巴毒素α的基因多态性
Genetic polymorphisms of the tumor necrosis factor and lymphotoxin alpha in type 2 diabetes.
作者信息
García-Elorriaga Guadalupe, Mendoza-Aguilar Melby, del Rey-Pineda Guillermo, González-Bonilla César
机构信息
Unidad de Investigación Médica en Immunología e Infectología, Hospital de Infectología, Centro Médico Nacional La Raza (CMNR), Instituto Mexican del Seguro Social (IMSS), Mexico City, Mexico.
出版信息
Rev Med Inst Mex Seguro Soc. 2013 Jan-Feb;51(1):42-9.
OBJECTIVE
To investigate the frequency of the single-base change polymorphic variants identified in tumor necrosis factor (TNF) gene (-308 G/A) and lymphotoxin alpha (LTA) (+252 G/A) in patients with type 2 diabetes (T2D).
METHODS
A prospective study in a Mexican-mestizo population of 51 patients with T2D and 48 healthy subjects was carried out. We took a peripheral blood sample from each individual for identification of the polymorphic genotypes by polymerase chain reaction.
RESULTS
The genotype distribution in T2D was: TNF alpha homozygous 0%; TNFG/A heterozygous 20%; TNFG homozygous 80%.
CONCLUSIONS
In regards to the TNF -308 G/A genotype, we found a significant difference (p = 0.012) with a bigger frequency in the group of patients. The health controls showed a higher frequency of TNF -308 G/G genotype (p = 0.034).
目的
研究肿瘤坏死因子（TNF）基因（-308 G/A）和淋巴毒素α（LTA）（+252 G/A）中鉴定出的单碱基变化多态性变体在2型糖尿病（T2D）患者中的出现频率。
方法
对51例T2D患者和48名健康受试者的墨西哥混血人群进行了一项前瞻性研究。我们从每个个体采集外周血样本，通过聚合酶链反应鉴定多态性基因型。
结果
T2D中的基因型分布为：TNFα纯合子0%；TNFG/A杂合子20%；TNFG纯合子80%。
结论
关于TNF -308 G/A基因型，我们发现患者组的频率更高，存在显著差异（p = 0.012）。健康对照组中TNF -308 G/G基因型的频率更高（p = 0.034）。
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