内耳细胞命运决定过程中的 Notch 信号通路
Notch signaling during cell fate determination in the inner ear.
机构信息
Department of Ophthalmology, University of Rochester, Rochester, NY 14642, United States.
出版信息
Semin Cell Dev Biol. 2013 May;24(5):470-9. doi: 10.1016/j.semcdb.2013.04.002. Epub 2013 Apr 8.
Abstract
In the inner ear, Notch signaling has been proposed to specify the sensory regions, as well as regulate the differentiation of hair cells and supporting cell within those regions. In addition, Notch plays an important role in otic neurogenesis, by determining which cells differentiate as neurons, sensory cells and non-sensory cells. Here, I review the evidence for the complex and myriad roles Notch participates in during inner ear development. A particular challenge for those studying ear development and Notch is to decipher how activation of a single pathway can lead to different outcomes within the ear, which may include changes in the intrinsic properties of the cell, Notch modulation, and potential non-canonical pathways.
摘要
在内耳中，Notch 信号通路被提出用于特化感觉区域，并调节这些区域内毛细胞和支持细胞的分化。此外，Notch 在耳神经发生中也起着重要作用，决定哪些细胞分化为神经元、感觉细胞和非感觉细胞。在这里，我综述了 Notch 在内耳发育过程中参与的复杂多样的作用的证据。对于研究耳朵发育和 Notch 的人来说，一个特别的挑战是要破解为什么激活单一通路在内耳中会导致不同的结果，这可能包括细胞内在特性的改变、Notch 调节以及潜在的非经典途径。
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