Department of Psychiatry, 9500 Gilman Drive, Dept. 9111N-1, La Jolla, CA 92093-9111, USA.
Br J Psychiatry. 2013 Jul;203(1):65-72. doi: 10.1192/bjp.bp.112.118547. Epub 2013 Apr 11.
Some data suggest that older adults with anxiety disorders do not respond as well to treatment as do younger adults.
We examined age differences in outcomes from the Coordinated Anxiety Learning and Management (CALM) study, an effectiveness trial comparing usual care to a computer-assisted collaborative care intervention for primary care patients with panic disorder, generalised anxiety disorder, post-traumatic stress disorder (PTSD), and/or social anxiety disorder. This is the first study to examine the efficacy of a collaborative care intervention in a sample that included both younger and older adults with anxiety disorders. We hypothesised that older adults would show a poorer response to the intervention than younger adults.
We examined findings for the overall sample, as well as within each diagnostic category (clinicaltrials.gov identifier: NCT00347269).
The CALM intervention was more effective than usual care among younger adults overall and for those with generalised anxiety disorder, panic disorder and social anxiety disorder. Among older adults, the intervention was effective overall and for those with social anxiety disorder and PTSD but not for those with panic disorder or generalised anxiety disorder. The effects of the intervention also appeared to erode by the 18-month follow-up, and there were no significant effects on remission among the older adults.
These results are consistent with the findings of other investigators suggesting that medications and psychotherapy for anxiety disorders may not be as effective for older individuals as they are for younger people.
一些数据表明,焦虑障碍的老年患者对治疗的反应不如年轻患者好。
我们研究了 Coordinated Anxiety Learning and Management(CALM)研究的结果中的年龄差异,该研究是一项有效性试验,比较了常规护理与计算机辅助协同护理干预对惊恐障碍、广泛性焦虑障碍、创伤后应激障碍(PTSD)和/或社交焦虑障碍的初级保健患者的影响。这是第一项在包括年轻和老年焦虑障碍患者的样本中研究协同护理干预效果的研究。我们假设老年患者对干预的反应会比年轻患者差。
我们检查了总体样本的结果,以及每个诊断类别(clinicaltrials.gov 标识符:NCT00347269)内的结果。
CALM 干预在年轻患者中总体上以及在广泛性焦虑障碍、惊恐障碍和社交焦虑障碍患者中比常规护理更有效。在老年患者中,干预总体上有效,对社交焦虑障碍和 PTSD 患者有效,但对惊恐障碍或广泛性焦虑障碍患者无效。干预的效果似乎在 18 个月的随访中逐渐减弱,而且对老年患者的缓解没有显著影响。
这些结果与其他研究人员的发现一致,即焦虑障碍的药物治疗和心理治疗对老年人可能不如对年轻人有效。