免疫球蛋白基因与重组腺病毒 HIV 疫苗随机临床试验中 HIV 感染的获得。
Immunoglobulin genes and the acquisition of HIV infection in a randomized trial of recombinant adenovirus HIV vaccine.
机构信息
Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
出版信息
Virology. 2013 Jun 20;441(1):70-4. doi: 10.1016/j.virol.2013.03.007. Epub 2013 Apr 11.
Our knowledge of the host genetic factors that contribute to the acquisition of HIV infection is limited. To identify the host genetic correlates of HIV1 acquisition, we genotyped 777 participants of a randomized trial of recombinant adenovirus HIV1 vaccine for Fcγ receptor IIa (FcγRIIa), FcγRIIIa, and several GM and KM alleles-genetic markers of immunoglobulin γ and κ chains, respectively. None of the genotypes by itself was significantly associated with the acquisition of HIV1 infection. However, particular combinations of GM and KM as well as those of GM and FcγRIIIa loci were significantly associated with the acquisition of HIV1 infection epistatically: KM1/3-GM3/17 (interaction p=0.0246; FDR=0.2952), KM1/3-GM5/21 (interaction p=0.0016; FDR=0.0960), and GM23+/-FcγRIIIa (interaction p=0.0060; FDR=0.1200). These results suggest the involvement of GM, KM, and FcγRIIIa loci in the acquisition of HIV infection. Additional studies are warranted.
我们对导致人类免疫缺陷病毒（HIV）感染的宿主遗传因素的了解有限。为了确定 HIV1 获得的宿主遗传相关性，我们对重组腺病毒 HIV1 疫苗的一项随机试验中的 777 名参与者进行了 Fcγ 受体 IIa（FcγRIIa）、FcγRIIIa 和几个 GM 和 KM 等位基因（分别为免疫球蛋白 γ 和 κ 链的遗传标记）的基因分型。单独的基因型本身与 HIV1 感染的获得均无显著相关性。然而，GM 和 KM 以及 GM 和 FcγRIIIa 基因座的特定组合与 HIV1 感染的获得呈上位性显著相关：KM1/3-GM3/17（相互作用 p=0.0246； FDR=0.2952），KM1/3-GM5/21（相互作用 p=0.0016； FDR=0.0960），以及 GM23+/ -FcγRIIIa（相互作用 p=0.0060； FDR=0.1200）。这些结果表明 GM、KM 和 FcγRIIIa 基因座参与了 HIV 感染的获得。需要进一步的研究。
Zotero 插件