菜粉蝶（鳞翅目）几丁寡糖的降血脂活性。
Hypolipidemic activity of the chitooligosaccharides from Clanis bilineata (Lepidoptera), an edible insect.
机构信息
School of Marine Science and Technology, HuaiHai Institute of Technology, 59 Cangwu Road, Xinpu 222005, China.
出版信息
Int J Biol Macromol. 2013 Aug;59:96-8. doi: 10.1016/j.ijbiomac.2013.04.017. Epub 2013 Apr 13.
Clanis bilineata (CB) is an edible insect, and CB larvae (CBL) are widely consumed in China, yielding a large number of CBL skin (CBLS). In this study, chitooligosaccharides (COS) from CBLS were prepared and their hypolipidemic activity was determined in rats. Thirty-six male Sprague-Dawley rats in 3 groups were fed diets containing either high fat (HF) or COS, or a normal fat (NF) for 6 weeks. Compared with HF group, COS group showed decreased body weight gain, plasma triacylglycerol (TG), total cholesterol (TC), and plasma low-density lipoprotein cholesterol (LDL-C) level. Fecal fat and cholesterol of the COS group were higher than those of NF and HF groups. The results indicated that COS could be a suitable alterative hypolipidemic source for humans.
双线豆芫菁（CB）是一种可食用昆虫，其幼虫（CBL）在中国被广泛食用，产生了大量的 CBL 皮（CBLS）。在本研究中，从 CBLS 中制备了壳寡糖（COS），并在大鼠中测定了其降血脂活性。36 只雄性 Sprague-Dawley 大鼠分为 3 组，分别给予高脂肪（HF）、COS 或正常脂肪（NF）饲料 6 周。与 HF 组相比，COS 组体重增加、血浆三酰甘油（TG）、总胆固醇（TC）和血浆低密度脂蛋白胆固醇（LDL-C）水平降低。COS 组粪便中的脂肪和胆固醇含量高于 NF 组和 HF 组。结果表明，COS 可能是一种适合人类的降血脂替代物。
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