用平衡法测定药物溶液的空气湿度渗透压。
Determining osmotic pressure of drug solutions by air humidity in equilibrium method.
机构信息
Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University , Chengdu, Sichuan , P. R. China.
出版信息
Drug Dev Ind Pharm. 2014 Jun;40(6):758-61. doi: 10.3109/03639045.2013.782555. Epub 2013 Apr 18.
OBJECTIVE
To establish a new osmotic pressure measuring method with a wide measuring range.
METHOD
The osmotic pressure of drug solutions is determined by measuring the relative air humidity in equilibrium with the solution. The freezing point osmometry is used as a control.
RESULTS
The data obtained by the proposed method are comparable to those by the control method, and the measuring range of the proposed method is significantly wider than that of the control method.
CONCLUSION
The proposed method is performed in an isothermal and equilibrium state, so it overcomes the defects of the freezing point and dew point osmometries which result from the heterothermal process in the measurement, and therefore is not limited to diluted solutions.
目的
建立一种新的渗透压测量方法，具有较宽的测量范围。
方法
通过测量与溶液平衡的相对空气湿度来确定药物溶液的渗透压。冰点渗透压计用作对照。
结果
所提出的方法得到的数据与对照方法得到的数据相当，并且该方法的测量范围明显大于对照方法的测量范围。
结论
该方法在等温平衡状态下进行，因此克服了冰点和露点渗透压计在测量中由于非均相过程而产生的缺陷，因此不受限于稀溶液。
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