Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, RO-400012, Victor Babes 41, Cluj-Napoca, Romania.
Molecules. 2013 Apr 19;18(4):4679-88. doi: 10.3390/molecules18044679.
New aryl-hydrazinyl-1,3-selenazole and aroyl-hydrazonyl-1,3-selenazoles were synthesized via Hantzsch type condensation reactions of selenosemicarbazides with α-halogenocarbonyl derivatives, under classical versus microwave heating conditions. Excellent yields and shorter reaction times were obtained under irradiation conditions. The structures of the synthesized compounds were assigned based on spectroscopic data (FT-IR, ¹H-NMR), MS and elemental analysis. Selenazole derivatives were screened for their anti-proliferative effects against two leukemia cell lines (CCRF-CEM and HL60) and three carcinoma cell lines (MDA-MB231, HCT116 and U87MG).
新型芳基腙基-1,3-硒唑和酰基腙基-1,3-硒唑通过硒代氨基甲脒与α-卤代羰基衍生物的 Hantzsch 型缩合反应合成，在经典加热与微波加热条件下进行。在辐照条件下，产率优异，反应时间更短。根据光谱数据（FT-IR、¹H-NMR、MS 和元素分析）确定合成化合物的结构。对硒唑衍生物进行了抗增殖活性筛选，针对两种白血病细胞系（CCRF-CEM 和 HL60）和三种癌细胞系（MDA-MB231、HCT116 和 U87MG）进行了筛选。
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