健康成年人的骨骼肌面积与体表面积呈正相关。

Skeletal muscle area correlates with body surface area in healthy adults.

机构信息

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

出版信息

Hepatol Res. 2014 Mar;44(3):313-8. doi: 10.1111/hepr.12119. Epub 2013 Apr 24.

DOI:10.1111/hepr.12119

PMID:23607375

Abstract

AIM

Depletion of skeletal muscle mass (sarcopenia) predicts survival in patients with cancer or liver cirrhosis. Recently, many reports have used computed tomography (CT) to measure muscle area to define sarcopenia. However, the definition of sarcopenia using CT has not been fully determined. The aim of this study was to establish formulae to calculate the standard area of skeletal muscle.

METHODS

Forty-five healthy adults (24 men and 21 women, aged 21-66 years) who wished to donate part of their liver for transplantation underwent CT. Cross-sectional areas (cm(2) ) of skeletal muscle were measured at the caudal end of the third lumbar vertebra. Regression analysis was performed to establish formulae to calculate the standard area of skeletal muscle. A validation conducted on 30 other healthy adults was performed to check the accuracy of formulae.

RESULTS

Men had a median skeletal muscle area of 155.0 cm(2) (range, 114.0-203.0), compared with 111.7 cm(2) (range, 89.8-139.3) in women (P < 0.001). Furthermore, skeletal muscle area significantly correlated with body surface area (BSA) in men (P < 0.0001, r(2) = 0.60) and women (P < 0.0001, r(2) = 0.78). The formulae to calculate skeletal muscle area were 126.9 × BSA - 66.2 in men and 125.6 × BSA - 81.1 in women. The estimated muscle area significantly correlated with actual muscle area in men (P = 0.003, r(2) = 0.64) and women (P = 0.0001, r(2) = 0.70).

CONCLUSION

Sarcopenia can be defined by the difference between measured data and calculated data using our new formulae.

摘要

目的

骨骼肌减少（肌少症）预测癌症或肝硬化患者的生存率。最近，许多报告使用计算机断层扫描（CT）来测量肌肉面积以定义肌少症。然而，使用 CT 定义肌少症尚未完全确定。本研究的目的是建立计算骨骼肌标准面积的公式。

方法

45 名健康成年人（24 名男性和 21 名女性，年龄 21-66 岁）希望为肝移植捐献部分肝脏，接受 CT 检查。在第三腰椎尾端测量骨骼肌的横截面积（cm²）。进行回归分析以建立计算骨骼肌标准面积的公式。在另外 30 名健康成年人中进行验证以检查公式的准确性。

结果

男性的骨骼肌面积中位数为 155.0cm²（范围，114.0-203.0），女性为 111.7cm²（范围，89.8-139.3）（P<0.001）。此外，骨骼肌面积与男性的体表面积（BSA）显著相关（P<0.0001，r²=0.60）和女性（P<0.0001，r²=0.78）。计算骨骼肌面积的公式为男性 126.9×BSA-66.2，女性 125.6×BSA-81.1。男性（P=0.003，r²=0.64）和女性（P=0.0001，r²=0.70）中，估计的肌肉面积与实际肌肉面积显著相关。