Department of Nephrology and Institute for Cardiovasculair Research of Vrije Universiteit, Vrije Universiteit University Medical Center, Amsterdam, The Netherlands.
J Ren Nutr. 2013 May;23(3):246-9. doi: 10.1053/j.jrn.2013.02.004.
In patients with advanced renal failure or those undergoing dialysis, protein energy wasting (PEW) is a frequently occurring complication that is associated with increased cardiovascular morbidity and mortality. Fewer data are available for patients after transplantation. In this article, the available data on nutritional status after kidney transplantation is reviewed. It was also found that signs of PEW and microinflammation in patients undergoing kidney transplantation are associated with both impaired transplantation outcomes and decreased patient survival. Data are lacking on nutritional support and outcomes after transplantation. Only 1 study revealed a possible relationship between healthier eating habits and better outcomes in patients who have undergone transplantation. More data support the notion that sufficient physical exercise improves graft survival and patient outcome after kidney transplantation. Future studies on nutritional support in patients with signs of PEW and microinflammation immediately after transplantation could reveal whether such a strategy improves renal and patient outcomes.
在患有晚期肾衰竭或正在接受透析的患者中,蛋白质能量消耗(PEW)是一种常见的并发症,与增加心血管发病率和死亡率有关。对于移植后的患者,可用的数据较少。本文回顾了肾移植后营养状况的现有数据。研究还发现,接受肾移植的患者出现 PEW 和微炎症的迹象与移植结局受损和患者生存率降低有关。关于移植后的营养支持和结果的数据尚缺乏。只有一项研究表明,移植后患者的健康饮食习惯与更好的结果之间可能存在关联。更多的数据支持这样一种观点,即充足的体育锻炼可以提高肾移植后的移植物存活率和患者预后。对移植后立即出现 PEW 和微炎症迹象的患者进行营养支持的未来研究可能会揭示这种策略是否可以改善肾脏和患者的预后。