Uysal B, Sager O, Gamsiz H, Cicek A, Demiral S, Dincoglan F, Surenkok S, Demiriz M, Beyzadeoglu M
Department of Radiation Oncology, Gulhane Military Medical Academy, Ankara, Turkey.
J BUON. 2013 Jan-Mar;18(1):268-73.
The aim of this study was to evaluate the role of radiotherapy (RT) in the management of dermatofibrosarcoma protuberans (DFSP).
Twenty-eight patients treated with RT for DFSP between 1974 and 2012 at Gulhane Military Medical Academy (GMMA) Radiation Oncology Department were retrospectively evaluated. Twenty-five out of 28 patients (89%) received postoperative RT and 3 received definitive RT alone. In the 25 patients receiving postoperative RT, the type of surgical excision was limited excision in 5 patients and wide excision in the remaining 20. Median RT dose was 63.21±3.7 Gy (range 50-70).
At a median follow-up of 5 years, 5-year overall survival (OS) for the whole patient group was 93%. No relationship was determined between the total delivered RT dose and OS. The 5-year OS of the 10 female patients was 90% whereas it was 94% for the 18 male patients (p>0.05). Five-year disease-free survival (DFS) for the patients undergoing wide excision with RT vs. those undergoing limited excision with RT was significantly superior (p <0.05) in patients treated with wide excision and RT.
RT is an effective treatment option for DFSP patients with positive postoperative margins, recurrent disease and selected inoperable cases.
本研究旨在评估放射治疗（RT）在隆突性皮肤纤维肉瘤（DFSP）治疗中的作用。
对1974年至2012年间在盖勒哈内军事医学院（GMMA）放射肿瘤学部门接受RT治疗的28例DFSP患者进行回顾性评估。28例患者中有25例（89%）接受了术后RT，3例仅接受了根治性RT。在接受术后RT的25例患者中，5例手术切除类型为局限性切除，其余20例为广泛切除。中位RT剂量为63.21±3.7 Gy（范围50 - 70）。
中位随访5年时，整个患者组的5年总生存率（OS）为93%。未确定总RT剂量与OS之间的关系。10例女性患者的5年OS为90%，而18例男性患者为94%（p>0.05）。接受广泛切除联合RT治疗的患者与接受局限性切除联合RT治疗的患者相比，5年无病生存率（DFS）显著更高（p<0.05）。
对于术后切缘阳性、复发性疾病及部分不可手术的DFSP患者，RT是一种有效的治疗选择。
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