沙雷氏菌属临床分离株对抗菌药物的体外敏感性

In-vitro susceptibility of clinical isolates of Serratia species to antimicrobial agents.

作者信息

Sofianou D, Proya E, Kondodimou A

机构信息

Department of Medical Microbiology, Aristotelian University of Thessaloniki, Greece.

出版信息

J Chemother. 1990 Apr;2(2):79-81. doi: 10.1080/1120009x.1990.11738987.

DOI:10.1080/1120009x.1990.11738987

PMID:2362189

Abstract

The in-vitro activities of 12 antimicrobial agents against a total of 80 clinical isolates of Serratia marcescens and Serratia liquefaciens were determined by a broth microdilution method. Ampicillin and cefazolin were totally inactive against these organisms. The other beta-lactam antibiotics such as piperacillin, cefotaxime, ceftazidime, and the aminoglycosides such as gentamicin, tobramycin and netilmicin showed poor or moderate activity against Serratia isolates. Aztreonam and amikacin inhibited most of the strains tested. Imipenem and ciprofloxacin were very active in inhibiting all strains. Within the genus, S. liquefaciens was more resistant to aztreonam, ceftazidime and amikacin than S. marcescens.

摘要

采用肉汤微量稀释法测定了12种抗菌药物对80株粘质沙雷氏菌和液化沙雷氏菌临床分离株的体外活性。氨苄西林和头孢唑林对这些菌株完全无活性。其他β-内酰胺类抗生素如哌拉西林、头孢噻肟、头孢他啶，以及氨基糖苷类抗生素如庆大霉素、妥布霉素和奈替米星对沙雷氏菌分离株显示出较差或中等活性。氨曲南和阿米卡星抑制了大多数测试菌株。亚胺培南和环丙沙星在抑制所有菌株方面非常有效。在该属内，液化沙雷氏菌比粘质沙雷氏菌对氨曲南、头孢他啶和阿米卡星更具耐药性。