钯催化 2-芳基吡啶衍生物的邻位酰化反应，使用芳基甲基胺作为新的酰化源。
Palladium-catalyzed ortho-acylation of 2-aryl pyridine derivatives using arylmethyl amines as new acyl sources.
机构信息
The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Zhengzhou University, Zhengzhou 450052, People's Republic of China.
出版信息
Chem Commun (Camb). 2013 Aug 7;49(61):6837-9. doi: 10.1039/c3cc42106f.
PMID:23629481
Abstract
A facile and efficient protocol for palladium-catalyzed ortho-acylation of 2-aryl pyridines was developed. Note that this acylation utilized arylmethyl amines as new, cheap and readily available acylation reagents and exhibited high regioselectivity for 2-aryl pyridines bearing a meta-substituent in the aryl ring moiety.
摘要
开发了一种简便高效的钯催化 2-芳基吡啶邻位酰化反应的方法。需要注意的是，该酰化反应使用芳基甲基胺作为新型、廉价且易得的酰化试剂，并对芳环部分带有间位取代基的 2-芳基吡啶具有高区域选择性。
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