手术切除在脑转移瘤患者中的作用。
The role of surgical resection in patients with brain metastases.
作者信息
Hatiboglu Mustafa Aziz, Wildrick David M, Sawaya Raymond
机构信息
Department of Neurosurgery, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey.
出版信息
Ecancermedicalscience. 2013 Apr 18;7:308. doi: 10.3332/ecancer.2013.308. Print 2013.
Brain metastasis is a devastating complication of systemic malignancy that affects a considerable number of cancer patients. The appearance of brain metastases is often considered to be a sign of poor prognosis; in patients with brain metastases poor survival time has been reported in the literature. Therefore, treatment of these brain lesions in cancer patients is important for quality of life, providing local tumour control, preventing death from neurological causes, and improving survival, although potentially only in a minority of patients. Surgical resection of brain metastases has been the cornerstone treatment in select patients. Careful patient selection, the use of appropriate surgical techniques, and surgical adjuncts are the major determinants of favourable outcome in patients undergoing resection of brain metastases. In this review, we explain the role of surgical resection in the treatment of patients with brain metastases with consideration of patient selection, surgical techniques and the use of intraoperative adjuncts.
脑转移是全身恶性肿瘤的一种毁灭性并发症，影响着相当数量的癌症患者。脑转移的出现通常被认为是预后不良的标志；文献报道脑转移患者的生存时间较短。因此，治疗癌症患者的这些脑病灶对于提高生活质量、实现局部肿瘤控制、预防神经源性死亡以及改善生存至关重要，尽管可能仅对少数患者有效。脑转移瘤的手术切除一直是部分患者的基石性治疗方法。仔细的患者选择、适当手术技术的运用以及手术辅助手段是脑转移瘤切除患者取得良好预后的主要决定因素。在本综述中，我们结合患者选择、手术技术和术中辅助手段的使用，阐述手术切除在脑转移瘤患者治疗中的作用。
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