Vascular endothelial growth factor and its receptors in the placental villi of pregnant patients with pre-eclampsia.
作者信息
Dubova E A, Pavlov K A, Lyapin V M, Shchyogolev A I, Sukhikh G T
机构信息
V. I. Kulakov Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health and Social Development of the Russian Federation, Moscow, Russia.
出版信息
Bull Exp Biol Med. 2013 Apr;154(6):792-5. doi: 10.1007/s10517-013-2058-8.
Comparative morphological study of the placentas from women with pre-eclampsia of different severity was carried out. The expression of vascular endothelial growth factor and its receptors (VEGFR-1, VEGFR-2, VEGFR-3) was studied by immunohistochemical methods. Branched angiogenesis processes predominated in the placentas of patients with pre-eclampsia. The syncytiocapillary membranes were thickened, the number of syncytial buds was greater than normally. Immunohistochemical studies showed high expression of VEGF and VEGFR-1 and low expression of VEGFR-2 in the placental villous structures.
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