胰腺癌基因组学：临床转化的见解与机遇。
Pancreatic cancer genomics: insights and opportunities for clinical translation.
机构信息
Graduate Program in Pathobiology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA ; Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA ; Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA ; Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
出版信息
Genome Med. 2013 Mar 28;5(3):26. doi: 10.1186/gm430. eCollection 2013.
Pancreatic cancer is a highly lethal tumor type for which there are few viable therapeutic options. It is also caused by the accumulation of mutations in a variety of genes. These genetic alterations can be grouped into those that accumulate during pancreatic intraepithelial neoplasia (precursor lesions) and thus are present in all cells of the infiltrating carcinoma, and those that accumulate specifically within the infiltrating carcinoma during subclonal evolution, resulting in genetic heterogeneity. Despite this heterogeneity there are nonetheless commonly altered cellular functions, such as pathways controlling the cell cycle, DNA damage repair, intracellular signaling and development, which could provide for a variety of drug targets. This review aims to summarize current knowledge of the genetics and genomics of pancreatic cancer from its inception to metastatic colonization, and to provide examples of how this information can be translated into the clinical setting for therapeutic benefit and personalized medicine.
胰腺癌是一种高度致命的肿瘤类型，目前几乎没有可行的治疗选择。它也是由多种基因的突变积累引起的。这些遗传改变可以分为在胰腺上皮内瘤变（前病变）期间积累的那些，因此存在于浸润性癌的所有细胞中，以及在亚克隆进化过程中特异性积累于浸润性癌中的那些，导致遗传异质性。尽管存在这种异质性，但仍存在一些常见的改变的细胞功能，例如控制细胞周期、DNA 损伤修复、细胞内信号转导和发育的途径，这些途径可为各种药物靶点提供依据。这篇综述旨在总结从胰腺癌起始到转移定植过程中的遗传学和基因组学的现有知识，并举例说明如何将这些信息转化为临床治疗和个性化医学，以带来治疗获益。
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