Department of Biochemistry, School of Medicine, People's Friendship University of Russia, Moscow 117198, Russia.
Cancer Biol Med. 2012 Mar;9(1):9-17. doi: 10.3969/j.issn.2095-3941.2012.01.002.
Photodynamic therapy (PDT) is a minimally invasive and promising new method in cancer treatment. Cytotoxic reactive oxygen species (ROS) are generated by the tissue-localized non-toxic sensitizer upon illumination and in the presence of oxygen. Thus, selective destruction of a targeted tumor may be achieved. Compared with traditional cancer treatment, PDI has advantages including higher selectivity and lower rate of toxicity. The high degree of selectivity of the proposed method was applied to cancer diagnosis using fluorescence. This article reviews previous studies done on PDT treatment and photodetection of cervical intraepithelial neoplasia, vulvar intraepithelial neoplasia, ovarian and breast cancer, and PDT application in treating non-cancer lesions. The article also highlights the clinical responses to PDT, and discusses the possibility of enhancing treatment efficacy by combination with immunotherapy and targeted therapy.
光动力疗法（PDT）是一种在癌症治疗中具有微创和广阔前景的新方法。细胞毒性活性氧（ROS）由组织局部非毒性敏化剂在光照和氧气存在下产生。因此，可以实现对靶向肿瘤的选择性破坏。与传统癌症治疗相比，PDI 具有更高的选择性和更低的毒性发生率等优势。所提出的方法的高度选择性已应用于使用荧光进行癌症诊断。本文回顾了以前关于 PDT 治疗和宫颈上皮内瘤变、外阴上皮内瘤变、卵巢和乳腺癌的光探测以及 PDT 在治疗非癌病变中的应用的研究。文章还强调了 PDT 的临床反应，并讨论了通过与免疫疗法和靶向疗法相结合来提高治疗效果的可能性。
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