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将用于评估差异的彼得斯 - 贝尔森方法扩展至右删失的事件发生时间结局。

Extending the Peters-Belson approach for assessing disparities to right censored time-to-event outcomes.

作者信息

Eberly Lynn E, Hodges James S, Savik Kay, Gurvich Olga, Bliss Donna Z, Mueller Christine

机构信息

Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.

出版信息

Stat Med. 2013 Oct 15;32(23):4006-20. doi: 10.1002/sim.5835. Epub 2013 May 24.

Abstract

The Peters-Belson (PB) method was developed for quantifying and testing disparities between groups in an outcome by using linear regression to compute group-specific observed and expected outcomes. It has since been extended to generalized linear models for binary and other outcomes and to analyses with probability-based sample weighting. In this work, we extend the PB approach to right-censored survival analysis, including stratification if needed. The extension uses the theory and methods of expected survival on the basis of Cox regression in a reference population. Within the PB framework, among the groups to be compared, one group is chosen as the reference group, and outcomes in that group are modeled as a function of available predictors. By using this fitted model's estimated parameters, and the predictor values for a comparator group, the comparator group's expected outcomes are then calculated and compared, formally with testing and informally with graphics, with their observed outcomes. We derive the extension, show how we applied it in a study of incontinence in nursing home elderly, and discuss issues in implementing it. We used the 'survival' package in the R system to do computations.

摘要

彼得斯 - 贝尔森(PB)方法是通过使用线性回归来计算特定组的观察结果和预期结果,从而对某一结果中不同组之间的差异进行量化和检验。此后,该方法已扩展到用于二元及其他结果的广义线性模型以及基于概率的样本加权分析。在这项工作中,我们将PB方法扩展到右删失生存分析,如有需要还包括分层分析。该扩展基于参考人群中Cox回归的预期生存理论和方法。在PB框架内,在要比较的组中,选择一组作为参考组,并将该组中的结果建模为可用预测变量的函数。通过使用该拟合模型的估计参数以及比较组的预测变量值,然后计算比较组的预期结果,并通过正式的检验和非正式的图形方式将其与观察结果进行比较。我们推导了该扩展方法,展示了我们如何将其应用于一项针对养老院老年人失禁情况的研究,并讨论了实施过程中的问题。我们使用R系统中的 “survival” 包进行计算。

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