通过磷原子桥连的环化复分解反应制备含有 1,3-反式二醇单元的复杂亚基。
Phosphate-tether-mediated ring-closing metathesis for the preparation of complex 1,3-anti-diol-containing subunits.
机构信息
Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA.
出版信息
Chemistry. 2013 Jun 17;19(25):8088-93. doi: 10.1002/chem.201300913. Epub 2013 May 24.
Abstract
An array of examples of diastereoselective, phosphate-tether-mediated ring-closing metathesis reactions, which highlight the importance of product ring size and substrate stereochemical compatibility, as well as complexity, is reported. Studies focus primarily on the formation of bicyclo[n.3.1]phosphates, involving the coupling of C₂-symmetric dienediol subunits with a variety of simple, as well as complex, alcohol partners.
摘要
报告了一系列非对映选择性、磷酸酯键介导的环 closing metathesis 反应的例子，这些例子突出了产物环大小和底物立体化学相容性以及复杂性的重要性。研究主要集中在双环[n.3.1]磷酸酯的形成上，涉及 C₂对称二烯二醇亚基与各种简单和复杂醇配体的偶联。
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