一项关于运动后肌肉血浆蛋白变化的初步研究。
A pilot study of muscle plasma protein changes after exercise.
机构信息
Neuromuscular Research Unit 3342, Department of Neurology, Rigshospitalet, University of Copenhagen, Blegdamsvej 9, 2100, Copenhagen, Denmark.
出版信息
Muscle Nerve. 2014 Feb;49(2):261-6. doi: 10.1002/mus.23909. Epub 2013 Aug 30.
INTRODUCTION
Creatine kinase (CK) and myoglobin (Mb) do not possess all good qualities as biomarkers of skeletal muscle damage. We investigated the utility of troponin I (TnI) and telethonin (Tcap) as markers and examined their temporal profiles after skeletal muscle damage.
METHODS
Plasma profiles were measured before and after exercise in 3 groups: subjects affected by either Becker muscular dystrophy or McArdle disease, and healthy subjects.
RESULTS
Mb and TnI appeared early in the blood, and the increase of TnI was only observed in patients with muscle disease. The CK increase was more delayed in plasma. Tcap was not detectable at any time.
CONCLUSIONS
Our results suggest that TnI is a marker of more severe damage signifying sarcomeric damage, and it could therefore be an important supplement to CK and Mb in clinical practice. Tcap is not useful as a marker for skeletal muscle damage.
简介
肌酸激酶（CK）和肌红蛋白（Mb）作为骨骼肌损伤的生物标志物并非十全十美。本研究旨在探讨肌钙蛋白 I（TnI）和远心蛋白（Tcap）作为标志物的效用，并观察它们在骨骼肌损伤后的时间分布。
方法
3 组受试者（分别患有贝克型肌营养不良症或肌酸磷酸激酶缺乏症和健康受试者）在运动前后分别测量血浆分布情况。
结果
Mb 和 TnI 较早出现在血液中，且 TnI 增加仅见于肌肉疾病患者。CK 在血浆中的增加更为延迟。在任何时间均无法检测到 Tcap。
结论
我们的结果表明，TnI 是更严重的肌节损伤的标志物，因此它可能是 CK 和 Mb 在临床实践中的重要补充。Tcap 不能作为骨骼肌损伤的标志物。
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