Birnbaum Tobias, Langer Sigrid, Roeber Sigrun, von Baumgarten Louisa, Straube Andreas
Departments of Neurology, Ludwig-Maximilians University, Munich, Germany.
Neurol Int. 2013 Mar 21;5(1):e4. doi: 10.4081/ni.2013.e4. Print 2013 Feb 11.
B-cell activating factor belonging to the tumor necrosis factor family (BAFF) and a proliferating inducing ligand (APRIL) might play an important role in the pathogenesis of systemic B-cell malignancies. However, the BAFF/APRIL system has not been systematically evaluated in primary central nervous system lymphoma (PCNSL) to date. We assessed the expression of BAFF, APRIL and its receptors BAFF-R (BAFF receptor), BCMA (B-cell maturation antigen) and TACI (transmembrane activator and calcium modulator cyclophilin ligand interactor) in five PCNSL specimens by immunohistochemical staining. We found extensive expression of BAFF and weak to moderate expression of APRIL, BAFF-R, BCMA, and TACI in all specimens. CD20 positive cells showed expression of both ligands and receptors at the same time. Our results indicate that autocrine stimulation of the BAFF/APRIL system might be involved in the pathogenesis of PCNSL.
肿瘤坏死因子家族成员B细胞活化因子（BAFF）和增殖诱导配体（APRIL）可能在系统性B细胞恶性肿瘤的发病机制中发挥重要作用。然而，迄今为止，BAFF/APRIL系统尚未在原发性中枢神经系统淋巴瘤（PCNSL）中得到系统评估。我们通过免疫组织化学染色评估了5例PCNSL标本中BAFF、APRIL及其受体BAFF-R（BAFF受体）、BCMA（B细胞成熟抗原）和TACI（跨膜激活剂和钙调蛋白亲环素配体相互作用分子）的表达。我们发现所有标本中BAFF广泛表达，APRIL、BAFF-R、BCMA和TACI呈弱至中度表达。CD20阳性细胞同时表达这两种配体和受体。我们的结果表明，BAFF/APRIL系统的自分泌刺激可能参与了PCNSL的发病机制。
