飞龙掌血（芸香科）根提取物对瑞士白化小鼠的抗伤害感受和抗炎作用。
Antinocieptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice.
作者信息
Kariuki Hellen Nyambura, Kanui Titus Ikusya, Yenesew Abiy, Patel Nilesh, Mbugua Paul Mungai
机构信息
University of Nairobi, Nairobi, Kenya.
出版信息
Pan Afr Med J. 2013 Apr 6;14:133. doi: 10.11604/pamj.2013.14.133.2130. Print 2013.
INTRODUCTION
Toddalia asiatica is a commonly used medicinal plant in East Africa for the management of pain and inflammatory conditions. The present study investigated the antinociceptive and the anti-inflammatory effects of T. asiatica in Swiss albino mice.
METHODS
The antinociceptive and the anti-inflammatory effects of T. asiatica were investigated using formalin-induced pain test and the carrageenin-induced oedema paw. The extract solvent (vehicle), aspirin and indomethacin were employed as negative and positive controls respectively. Eight mice were used in each experiment.
RESULTS
In the early phase of the formalin test, the 100mg/kg dose showed no significant antinociceptive activity while the 200mg/kg showed significant (p < 0.01) antinociceptive activity. The 100 mg/kg dose showed highly significant antinociceptive activity (p < 0.001) in the late phase of the formalin test while the 200mg/kg dose showed no significant antinociceptive activity. A reduction in carragenin induced acute inflammation paw oedema was significant (p < 0.01) following administration of 100mg/kg dose but not with the 200mg/kg dose.
CONCLUSION
The present study therefore lends support to the anecdotal evidence for use of T. asiatica in the management of painful and inflammatory conditions.
引言
非洲山柑是东非一种常用的药用植物，用于治疗疼痛和炎症。本研究调查了非洲山柑对瑞士白化小鼠的镇痛和抗炎作用。
方法
采用福尔马林诱导的疼痛试验和角叉菜胶诱导的爪部水肿试验，研究非洲山柑的镇痛和抗炎作用。提取物溶剂（赋形剂）、阿司匹林和吲哚美辛分别用作阴性和阳性对照。每个实验使用8只小鼠。
结果
在福尔马林试验的早期阶段，100mg/kg剂量未显示出显著的镇痛活性，而200mg/kg剂量显示出显著的（p < 0.01）镇痛活性。100mg/kg剂量在福尔马林试验的后期显示出高度显著的镇痛活性（p < 0.001），而200mg/kg剂量未显示出显著的镇痛活性。给予100mg/kg剂量后，角叉菜胶诱导的急性炎症爪部水肿有显著减轻（p < 0.01），但200mg/kg剂量则无此效果。
结论
因此，本研究为非洲山柑用于治疗疼痛和炎症的传闻证据提供了支持。
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