Department of Clinical Laboratory, Jiangsu Cancer Hospital & Nanjing Medical University Cancer Hospital, 42 Baiziting Road, Nanjing, 210009, Jiangsu, China.
Pathol Oncol Res. 2013 Oct;19(4):749-53. doi: 10.1007/s12253-013-9638-9. Epub 2013 Jun 5.
Recent studies have shown that expression of metastasis-associated in colon cancer-1(MACC1) is observed in different types of cancer and plays an important role in tumor metastasis. However, the expression of MACC1 and its possible role in esophageal cancer remains unknown. In this study, we determined the expression of MACC1 in esophageal cancer by utilizing immunohistochemistry and analyzed the relationship between the expression and esophageal cancer prognosis. Immunohistochemistry results showed that 47 of 85 cancer lesions (55.2 %) were stained positive, and high expression of MACC1 was correlated with the node metastasis and TNM stage (P < 0.05). The Kaplan-Meier survival curve showed that patients with high MACC1 expression had significantly reduced overall 5-year survival rates (P = 0.004). Cox regression analysis revealed that high expression of MACC1 was associated with increased risk of death (hazard ratio [HR] =2.25) in patients with esophageal cancer. These findings suggested that high expression of MACC1 was correlated with progression and metastasis of esophageal cancer and might serve as a novel prognostic marker for patients with esophageal cancer.
最近的研究表明，结肠癌转移相关基因 1（MACC1）的表达存在于不同类型的癌症中，并且在肿瘤转移中发挥着重要作用。然而，MACC1 的表达及其在食管癌中的可能作用尚不清楚。在这项研究中，我们通过免疫组织化学方法来确定 MACC1 在食管癌中的表达，并分析其表达与食管癌预后之间的关系。免疫组织化学结果显示，85 例癌病变中有 47 例（55.2%）染色阳性，MACC1 的高表达与淋巴结转移和 TNM 分期相关（P < 0.05）。Kaplan-Meier 生存曲线显示，MACC1 高表达的患者总 5 年生存率显著降低（P = 0.004）。Cox 回归分析显示，MACC1 高表达与食管癌患者死亡风险增加相关（危险比 [HR] =2.25）。这些发现表明，MACC1 的高表达与食管癌的进展和转移有关，可能成为食管癌患者的一种新的预后标志物。
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