Department of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403-1253, USA.
Angew Chem Int Ed Engl. 2013 Jul 15;52(29):7527-31. doi: 10.1002/anie.201302660. Epub 2013 Jun 7.
Getting the family together: A general synthetic strategy based on nucleophilic substitution provided B-substituted 1,3-dihydro-1,3-azaborines (see scheme), BN isosteres of arenes with potential for application in biomedicine and materials science. Experimental structural analysis and calculations suggest that the aromaticity of the 1,3-dihydro-1,3-azaborine heterocycle is intermediate between that of benzene and that of 1,2-dihydro-1,2-azaborine.
一种基于亲核取代的通用合成策略提供了 B 取代的 1,3-二氢-1,3-氮硼杂环(如图所示),这是芳烃的 BN 等排体,具有在生物医药和材料科学中的应用潜力。实验结构分析和计算表明,1,3-二氢-1,3-氮硼杂环的芳香性介于苯和 1,2-二氢-1,2-氮硼杂环之间。