Bulas J, Potočárová M, Filková M, Simková A, Murín J
Interná klinika Lekárskej fakulty UK a UN Bratislava, Slovenská republika.
Vnitr Lek. 2013 Jun;59(6):444-9.
Arterial stiffness increases as a result of degenerative processes accelerated by aging and many risk factors, namely arterial hypertension. Basic clinical examination reveals increased pulse pressure as its hemodynamic manifestation. The most serious consequence of increased vascular stiffness, which cannot be revealed by clinical examination, is a change of central hemodynamics leading to increased load of left ventricle, left ventricular hypertrophy, diastolic dysfunction and to overall increase of cardiovascular risk. This review aimed to point at some patophysiological mechanisms taking part in the development of vascular stiffness, vascular remodeling and hemodynamic consequences of these changes. This work also gives an overview of noninvasive examination methods and their characteristics enabling to evaluate the local, regional and systemic arterial stiffness and central pulse wave analysis and their meaning for central hemodynamics and heart workload.
由于衰老和许多风险因素（即动脉高血压）加速了退行性过程，动脉僵硬度增加。基本临床检查显示脉压增加是其血流动力学表现。血管僵硬度增加最严重的后果（临床检查无法发现）是中心血流动力学改变，导致左心室负荷增加、左心室肥厚、舒张功能障碍以及心血管风险总体增加。本综述旨在指出一些参与血管僵硬度发展、血管重塑以及这些变化的血流动力学后果的病理生理机制。这项工作还概述了无创检查方法及其特点，这些方法能够评估局部、区域和全身动脉僵硬度以及中心脉搏波分析，及其对中心血流动力学和心脏负荷的意义。
