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偏头痛的组学研究。

The omics in migraine.

机构信息

Sant'Andrea Hospital, Advanced Molecular Diagnostics Unit, Via di Grottarossa 1035 - 1039, Rome 00189, Italy.

出版信息

J Headache Pain. 2013 Jul 1;14(1):55. doi: 10.1186/1129-2377-14-55.

Abstract

The term omics consist of three main areas of molecular biology, such as genomics, proteomics and metabolomics. The omics synergism recognise migraine as an ideal study model, due to its multifactorial nature. In this review, the plainly research data featuring in this complex network are reported and analyzed, as single or multiple factor in pathophysiology of migraine. The future of migraine biomolecular research shall be focused on networking among these different and hierarchical disciplines. We have to look for its Ariadne's tread, in order to see the whole painting of migraine molecular biology.

摘要

组学一词包含分子生物学的三个主要领域,如基因组学、蛋白质组学和代谢组学。组学协同作用将偏头痛视为一个理想的研究模型,因为它具有多因素的性质。在这篇综述中,报告和分析了在偏头痛病理生理学中单或多个因素中呈现出的这一复杂网络的明显研究数据。偏头痛生物分子研究的未来将集中在这些不同和层次化学科之间的联网上。我们必须寻找它的阿里阿德涅线,以便看到偏头痛分子生物学的全貌。

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