无氧化剂条件下 Rh(III)催化芳基乙酸酯与烯烃的直接 C-H 烯丙基化反应
Oxidant-free Rh(III)-catalyzed direct C-H olefination of arenes with allyl acetates.
机构信息
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
出版信息
Org Lett. 2013 Jul 19;15(14):3670-3. doi: 10.1021/ol4015442. Epub 2013 Jul 1.
Rh(III)-catalyzed direct olefination of arenes with allyl acetate via C-H bond activation is described using N,N-disubstituted aminocarbonyl as the directing group. The catalyst undergoes a redox neutral process, and high to excellent yields of trans-products are obtained. This protocol exhibits a wide spectrum of functionality compatibility because of the simple reaction conditions employed and provides a highly effective synthetic method in the realm of C-H olefination.
描述了一种使用 N,N-二取代氨甲酰基作为导向基团，通过 C-H 键活化实现 Rh(III)催化芳基与烯丙基乙酸酯的直接烯烃化的方法。该催化剂经历了一个氧化还原中性过程，得到了高至优异的反式产物收率。由于采用了简单的反应条件，该方案表现出广泛的官能团兼容性，并为 C-H 烯烃化领域提供了一种高效的合成方法。
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