哺乳动物 X 染色体失活的进化途径。
The evolutionary pathway of x chromosome inactivation in mammals.
机构信息
Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Prospekt Lavrentyeva, 10, Novosibirsk, Russia, 630090 ; State Research Institute of Circulation Pathology, Rechkunovskaya Str., 15, Novosibirsk, Russia, 630055 ; Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Prospekt Lavrentyeva, 8, Novosibirsk, Russia, 630090.
出版信息
Acta Naturae. 2013 Apr;5(2):40-53.
X chromosome inactivation is a complex process that occurs in marsupial and eutherian mammals. The process is thought to have arisen during the differentiation of mammalian sex chromosomes to achieve an equal dosage of X chromosome genes in males and females. The differences in the X chromosome inactivation processes in marsupial and eutherian mammals are considered, and the hypotheses on its origin and evolution are discussed in this review.
X 染色体失活是一个复杂的过程，发生在有袋类和真兽类哺乳动物中。这个过程被认为是在哺乳动物性染色体分化过程中产生的，目的是在雄性和雌性中实现 X 染色体基因的均等剂量。本文考虑了有袋类和真兽类哺乳动物 X 染色体失活过程的差异，并讨论了其起源和进化的假说。
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