来自垂头菊的两种新的酚糖苷及其抗补体活性。

Two new phenolic glycosides from Gnaphalium affine D. Don and their anti-complementary activity.

机构信息

School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China.

出版信息

Molecules. 2013 Jul 3;18(7):7751-60. doi: 10.3390/molecules18077751.

DOI:10.3390/molecules18077751

PMID:23823875

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6270502/

Abstract

Two new phenolic glycosides, named gnaphaffine A and B (compounds 1 and 2), were isolated from Gnaphalium affine. together with six known compounds, including caffeic acid (3), everlastoside L (4), isorhamnetin-7-O-β-D-glucopyranoside (5), quercetin- 3-O-β-D-glucopyranoside (6), scutellarein-7-O-β-D-glucoside (7) and api-genin-7-O-β-D- glucopyranoside (8). Their structures were elucidated by spectroscopic methods, including ESI-MS and 2D NMR spectroscopy (HMQC and HMBC). All compounds were evaluated for their anti-complementary activity on the classical pathway of the complement system in vitro.

摘要

从鹅绒藤中分离得到了两个新的酚糖苷，分别命名为 gnaphaffine A 和 B（化合物 1 和 2）。此外，还分离得到了 6 个已知化合物，包括咖啡酸（3）、紫菀苷 L（4）、异鼠李素-7-O-β-D-吡喃葡萄糖苷（5）、槲皮素-3-O-β-D-吡喃葡萄糖苷（6）、野黄芩苷（7）和芹菜素-7-O-β-D-吡喃葡萄糖苷（8）。通过 ESI-MS 和二维 NMR 光谱（HMQC 和 HMBC）等光谱方法阐明了它们的结构。所有化合物均在体外对补体系统经典途径的抗补体活性进行了评价。