Department of Breast, Henan Cancer Hospital, Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou 450008, China.
Asian Pac J Trop Med. 2013 Sep;6(9):732-8. doi: 10.1016/S1995-7645(13)60128-5.
To analyze breast cancer bone metastasis related gene-CXCR4.
This research screened breast cancer bone metastasis related genes by high-flux gene chip.
It was found that the expressions of 396 genes were different including 165 up-regulations and 231 down-regulations. The expression of chemokine receptor CXCR4 was obviously up-regulated in the tissue with breast cancer bone metastasis. Compared with the tissue without bone metastasis, there was significant difference, which indicated that CXCR4 played a vital role in breast cancer bone metastasis.
The bioinformatics analysis of CXCR4 can provide a certain basis for the occurrence and diagnosis of breast cancer bone metastasis, target gene therapy and evaluation of prognosis.
分析乳腺癌骨转移相关基因—CXCR4。
本研究通过高通量基因芯片筛选乳腺癌骨转移相关基因。
发现 396 个基因的表达存在差异，其中 165 个上调，231 个下调。在乳腺癌骨转移组织中，趋化因子受体 CXCR4 的表达明显上调。与无骨转移组织相比，差异有统计学意义，表明 CXCR4 在乳腺癌骨转移中起重要作用。
对 CXCR4 的生物信息学分析可为乳腺癌骨转移的发生、诊断、靶基因治疗及预后评估提供一定的依据。
Zotero 插件