住院老年患者骨骼肌质量：单频生物电阻抗分析和双能 X 射线吸收法测量的比较。
Skeletal muscle mass in hospitalized elderly patients: comparison of measurements by single-frequency BIA and DXA.
机构信息
Clinical Nutrition Unit, Sahlgrenska University Hospital, Bruna stråket 11 plan 4, S-413 45 Gothenburg, Sweden.
Dept. of Medicine, Southern Clinical School, Monash University, Clayton, Victoria, Australia.
出版信息
Clin Nutr. 2014 Jun;33(3):426-31. doi: 10.1016/j.clnu.2013.06.007. Epub 2013 Jun 18.
BACKGROUND & AIMS: There is increasing interest in estimating skeletal muscle mass (SMM) in clinical practice. We aimed to validate a bioelectrical impedance analysis (BIA) prediction equation for SMM, developed in a different healthy elderly population, in a population of hospital patients aged 70 and over, by comparison with dual-energy X-ray absorptiometry (DXA) SMM estimates. Comparison was also made with two other previously published BIA muscle prediction equations.
METHODS
Muscle measurements by BIA and DXA were compared in 117 patients with a range of clinical conditions (45 female, 72 male, mean age 75 years).
RESULTS
The BIA equation used yielded an accurate estimate of DXA-derived SMM. Mean (SD) difference was 0.26(1.79) kg (ns). The two other BIA equations over-estimated SMM compared to DXA (both p < 0.001), but all equations were highly correlated.
CONCLUSIONS
The BIA equation used, developed in a different healthy elderly population, gave an accurate estimate of DXA-derived SMM in a population with various clinical disorders. BIA appears potentially capable to estimate SMM in clinical disorders, but the optimal approach to its use for this purpose requires further investigation.
背景与目的
临床实践中，人们对估算骨骼肌量（SMM）的兴趣日益增加。我们旨在通过与双能 X 射线吸收法（DXA）估算的 SMM 进行比较，验证在另一组健康老年人群中开发的用于估算 SMM 的生物电阻抗分析（BIA）预测方程在 70 岁及以上住院患者人群中的有效性，此外，我们还将该方程与另外两个之前发表的 BIA 肌肉预测方程进行了比较。
方法
比较了 117 例具有不同临床疾病（45 例女性，72 例男性，平均年龄 75 岁）患者的 BIA 和 DXA 肌肉测量值。
结果
所使用的 BIA 方程可以准确估算 DXA 测定的 SMM。平均（SD）差值为 0.26（1.79）kg（无统计学差异）。与 DXA 相比，另外两个 BIA 方程高估了 SMM（均<0.001），但所有方程的相关性均很高。
结论
在具有不同临床疾病的患者人群中，该在另一组健康老年人群中开发的 BIA 方程可以准确估算 DXA 测定的 SMM。BIA 似乎有可能用于估算临床疾病中的 SMM，但需要进一步研究其用于该目的的最佳方法。
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