National Institute Materials Physics, 105 bis Atomistilor, P.O. Box MG 07, 077125 Bucuresti-Magurele, Romania.
Mater Sci Eng C Mater Biol Appl. 2013 Apr 1;33(3):1395-402. doi: 10.1016/j.msec.2012.12.042. Epub 2012 Dec 16.
The aim of this study was to obtain a novel hydroxyapatite-based material with high biocompatibility. The structural properties of the samples were well characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and X-ray Photoelectron Spectroscopy (XPS). The X-ray diffraction studies revealed the characteristic peaks of hydroxyapatite in each sample. Other phases or impurities were not observed. The scanning electron microscopy observations suggest that the doping components have no influence on the surface morphology of the samples, which reveals a homogeneous aspect of the synthesized particles for all samples. The presence of calcium (Ca), phosphor (P), oxygen (O) and silver (Ag) in the Ag:HAp is confirmed by energy dispersive X-ray (EDAX) and X-ray Photoelectron Spectroscopy analyses. Nanocrystalline silver doped HAp stimulated viability and potentiated the activation of murine macrophages.
本研究旨在获得一种具有高生物相容性的新型羟基磷灰石基材料。通过 X 射线衍射（XRD）、扫描电子显微镜（SEM）和 X 射线光电子能谱（XPS）对样品的结构特性进行了很好的表征。X 射线衍射研究表明，每个样品都具有羟基磷灰石的特征峰。没有观察到其他相或杂质。扫描电子显微镜观察表明，掺杂成分对样品的表面形貌没有影响，这表明所有样品的合成颗粒都具有均匀的外观。通过能谱分析（EDAX）和 X 射线光电子能谱分析证实了 Ag:HAp 中存在钙（Ca）、磷（P）、氧（O）和银（Ag）。纳米晶银掺杂的 HAp 刺激了细胞活力并增强了小鼠巨噬细胞的激活。
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