Drug Ther Bull. 2013 Jul;51(7):81-4. doi: 10.1136/dtb.2013.7.0193. Epub 2013 Jul 4.
Actinic keratoses are common, often multiple, epidermal lesions found mainly on the sun-exposed skin of fair-skinned middle-aged and older people.(1) Over time, lesions may remain unchanged or may proliferate, regress, reappear or develop into squamous cell carcinoma (SCC).(2) Detectable (spot) lesions are often associated with alteration of the surrounding skin (field) where subclinical lesions might be present.(2) Interventions may target individual or multiple lesions or a whole field.(2) Here, we update our previous review(3) on the prevention and treatment of actinic keratoses, focusing on the licensed treatments most commonly used in the UK and recommended in UK guidelines.
光化性角化病很常见,通常为多发性表皮病变,主要见于皮肤白皙的中老年人暴露于阳光下的皮肤。(1)随着时间的推移,病变可能保持不变,也可能增殖、消退、复发或发展为鳞状细胞癌(SCC)。(2)可检测到的(点状)病变常与周围皮肤(区域)的改变相关,其中可能存在亚临床病变。(2)干预措施可针对单个或多个病变或整个区域。(2)在此,我们更新了之前关于光化性角化病预防和治疗的综述(3),重点关注英国最常用且英国指南推荐的获批治疗方法。