定植共生菌塑造免疫。
Resident commensals shaping immunity.
机构信息
Department of Microbiology and Immunobiology, Harvard Medical School, 77 Avenue Louis Pasteur, Room 1056C, Boston, MA 02115, United States.
出版信息
Curr Opin Immunol. 2013 Aug;25(4):450-5. doi: 10.1016/j.coi.2013.06.001. Epub 2013 Jul 2.
Abstract
All animals coexist with myriad commensal microorganisms in a symbiotic relationship that plays a key role in health and disease. Continuous commensal-host interactions profoundly affect the development and regulation of the host's immune system. The complex interaction of the commensal microbiota with the immune system is a topic of substantial interest. An understanding of these interactions and the mechanisms through which commensal microbes actively shape host immunity may yield new insights into the pathogenesis of many immune-mediated diseases and lead to new prophylactic and therapeutic interventions. This review examines recent advances in this field and their potential implications not just for the colonized tissues but also for the entire immune system.
摘要
所有动物都与无数共生微生物共存于一种共生关系中，这种关系在健康和疾病中起着关键作用。连续的共生体-宿主相互作用深刻地影响着宿主免疫系统的发育和调节。共生微生物与免疫系统的复杂相互作用是一个非常关注的话题。理解这些相互作用以及共生微生物积极塑造宿主免疫的机制，可能会为许多免疫介导的疾病的发病机制提供新的见解，并为新的预防和治疗干预措施提供依据。本综述考察了这一领域的最新进展及其潜在意义，不仅对被定植的组织，而且对整个免疫系统都有意义。
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