表没食子儿茶素没食子酸酯对大鼠脊髓损伤的抗水肿作用。
Anti-edema effect of epigallocatechin gallate on spinal cord injury in rats.
机构信息
Department of Orthopaedics, The First Affiliated Hospital of China Medical University, No.155 Nanjing North Street, Heping District, Shenyang 110001, Liaoning Province, PR China.
出版信息
Brain Res. 2013 Aug 21;1527:40-6. doi: 10.1016/j.brainres.2013.06.009. Epub 2013 Jul 4.
Recent studies indicated that epigallocatechin gallate (EGCG) had neuroprotective effects on spinal cord injury (SCI).The current study was performed to determine the anti-edema effect of EGCG after SCI in rats. EGCG (100 mg/kg, i.p.) was administered to rats immediately following SCI. It was found that EGCG (100 mg/kg) could significantly reduce spinal cord water content. In addition, EGCG (100mg/kg) significantly reduced the expression of aquaporin-4(AQP4) and glial fibrillary acidic protein (GFAP) level at 24, 48 and 72h after injury, but it did not have this effect at 12 h after injury. The changes of AQP4 and GFAP protein induced by EGCG (100 mg/kg) treatment were accompanied by a reduction of spinal cord edema. Our results indicated that EGCG (100 mg/kg) could reduce spinal cord edema after SCI, which could be correlated with the down-regulation the expression of AQP4 and GFAP protein level after SCI.
最近的研究表明，表没食子儿茶素没食子酸酯（EGCG）对脊髓损伤（SCI）具有神经保护作用。本研究旨在确定 EGCG 在大鼠 SCI 后的抗水肿作用。EGCG（100mg/kg，腹腔注射）在 SCI 后立即给予大鼠。结果发现，EGCG（100mg/kg）可显著降低脊髓含水量。此外，EGCG（100mg/kg）可显著降低损伤后 24、48 和 72h 时水通道蛋白 4（AQP4）和神经胶质纤维酸性蛋白（GFAP）的表达水平，但在损伤后 12h 时没有这种作用。EGCG（100mg/kg）治疗引起的 AQP4 和 GFAP 蛋白变化伴随着脊髓水肿的减少。我们的结果表明，EGCG（100mg/kg）可减轻 SCI 后的脊髓水肿，这可能与 SCI 后 AQP4 和 GFAP 蛋白水平的下调有关。
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