Centro de Investigação em Ciências da Saúde (CICS), Instituto Superior de Ciências da Saúde - Norte, CESPU. Rua Central de Gandra, 1317. 4585-116 Gandra PRD, Portugal.
Curr Med Chem. 2013;20(37):4744-57. doi: 10.2174/09298673113209990158.
Numerous studies in humans, animal models and cell lines have suggested the potential benefits from the consumption of green tea polyphenols, including prevention of cancer and heart diseases. However these potential effects have been strongly limited by green tea catechins low bioavailability, which hinders the development of therapeutic applications. In this review formulations that are being proposed for delivery of green tea catechins are discussed. New delivery systems are presented as valid alternatives to overcome the limitations such as green tea catechins poor stability or intestinal absorption.
大量的人体研究、动物模型和细胞系研究表明,绿茶多酚具有潜在的益处,包括预防癌症和心脏病。然而,这些潜在的效果受到绿茶儿茶素生物利用度低的强烈限制,这阻碍了治疗应用的发展。在这篇综述中,讨论了正在提出的用于输送绿茶儿茶素的配方。新的给药系统被提出作为克服绿茶儿茶素稳定性差或肠道吸收不良等限制的有效替代品。