Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Tokyo, Japan.
Implant Dent. 2013 Aug;22(4):422-7. doi: 10.1097/ID.0b013e31829d19f0.
This study examined the effect of basic fibroblast growth factor (FGF)-2 with an absorbable collagen sponge on angiogenesis and bone regeneration in rat calvarial critical-sized bone defects using microcomputed tomography.
Forty 7-week-old male Fischer rats were used. The symmetrical critical-sized calvarial bone defects (5 mm diameter) were created. An absorbable collagen sponge with or without FGF-2 (0.1% or 0.3%) was implanted into each bone defect.
Blood vessel and bone volumes were significantly higher in the 0.3% FGF-2 group compared with the control and 0.1% FGF-2 groups on day 28. Significantly more osteoblast- and osteoclast-like cells were seen in the 0.3% FGF-2 group.
Thus, FGF-2 increased blood vessel and bone formation in rat calvarial critical-sized bone defects.
本研究使用微计算机断层扫描技术，研究了在大鼠颅骨临界尺寸骨缺损中，碱性成纤维细胞生长因子（FGF）-2 与可吸收胶原海绵对血管生成和骨再生的影响。
使用 40 只 7 周龄雄性 Fischer 大鼠。创建了对称的临界尺寸颅骨骨缺损（5 毫米直径）。将含有或不含有 FGF-2（0.1%或 0.3%）的可吸收胶原海绵植入每个骨缺损中。
第 28 天，0.3% FGF-2 组的血管和骨体积明显高于对照组和 0.1% FGF-2 组。0.3% FGF-2 组中可见更多的成骨细胞和破骨细胞样细胞。
因此，FGF-2 增加了大鼠颅骨临界尺寸骨缺损中的血管和骨形成。
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