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美国卵巢癌幸存者相关问题:文献综述。

Issues of ovarian cancer survivors in the USA: a literature review.

机构信息

Division of Cancer Prevention and Control, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Highway, NE, MS F76, Atlanta, GA, 30341, USA,

出版信息

Support Care Cancer. 2013 Oct;21(10):2889-98. doi: 10.1007/s00520-013-1893-5. Epub 2013 Jul 12.

Abstract

PURPOSE

As the number of ovarian cancer survivors increases, so does the need for appropriate intervention and care. A literature review was conducted to assess the issues affecting ovarian cancer survivors in the USA, including the needs of younger survivors.

METHODS

Articles on six topics (finances/employment, reproductive and sexual health, treatment effects, information needs, genomics, and end-of-life/palliative care) among ovarian cancer survivors were identified through comprehensive database searches. Abstracts for all citations were reviewed to determine relevancy. Data from relevant articles, defined as including a sample size of ≥ 20, published in English, involving human subjects in the USA, and published between 2000 and 2010, were abstracted.

RESULTS

Thirty-four articles were relevant. Common, but often unaddressed, treatment side effects included infertility and issues with sexual health. Survivors reported not receiving adequate information about their disease. Hereditary cancer can lead to concern for family members. End-of-life/palliative care was often not addressed by physicians. Most of the studies used a cross-sectional design and lacked control groups. Participants were primarily recruited from academic medical centers or clinical trials and tended to be White. Few studies specifically addressed young survivors; however, reproductive health issues are common.

CONCLUSIONS

Ovarian cancer has wide-ranging impacts. This review emphasizes the need for more research among ovarian cancer survivors, particularly related to finances, reproductive and sexual health, information, genomics, and end-of-life care. Issues specific to young survivors also deserve more attention. Direction for future research and clinical implications are discussed.

摘要

目的

随着卵巢癌幸存者人数的增加,对适当干预和护理的需求也在增加。进行了文献回顾,以评估影响美国卵巢癌幸存者的问题,包括年轻幸存者的需求。

方法

通过全面的数据库搜索,确定了卵巢癌幸存者的六个主题(财务/就业、生殖和性健康、治疗效果、信息需求、基因组学和临终/姑息治疗)的文章。对所有引文的摘要进行了审查,以确定相关性。将数据从符合以下条件的相关文章中提取出来:样本量≥20、发表在英语、涉及美国人类受试者、发表时间在 2000 年至 2010 年之间。

结果

有 34 篇文章是相关的。常见但往往未得到解决的治疗副作用包括不孕和性健康问题。幸存者报告说,他们没有得到关于自己疾病的足够信息。遗传性癌症会引起家庭成员的担忧。医生往往没有解决临终/姑息治疗问题。大多数研究采用横断面设计,缺乏对照组。参与者主要从学术医疗中心或临床试验中招募,且往往是白人。很少有研究专门针对年轻幸存者,但生殖健康问题很常见。

结论

卵巢癌的影响范围很广。这篇综述强调了需要对卵巢癌幸存者进行更多的研究,特别是关于财务、生殖和性健康、信息、基因组学和临终关怀的研究。年轻幸存者的特殊问题也值得更多关注。讨论了未来研究的方向和临床意义。

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