GPR43 的治疗潜力：调节代谢健康的新作用。
The therapeutic potential of GPR43: a novel role in modulating metabolic health.
机构信息
Biomedical and Lifestyle Diseases Unit, College of Health and Biomedicine, Victoria University, PO Box 14428, Melbourne, VIC, 8001, Australia,
出版信息
Cell Mol Life Sci. 2013 Dec;70(24):4759-70. doi: 10.1007/s00018-013-1419-9. Epub 2013 Jul 14.
Abstract
GPR43 is a receptor for short-chain fatty acids. Preliminary data suggest a putative role for GPR43 in regulating systemic health via processes including inflammation, carcinogenesis, gastrointestinal function, and adipogenesis. GPR43 is involved in secretion of gastrointestinal peptides, which regulate appetite and gastrointestinal motility. This suggests GPR43 may have a role in weight control. Moreover, GPR43 regulates plasma lipid profile and inflammatory processes, which further indicates that GPR43 could have the ability to modulate the etiology and pathogenesis of metabolic diseases such as obesity, type 2 diabetes mellitus, and cardiovascular disease. This review summarizes the current evidence regarding the ability of GPR43 to mediate both systemic and tissue specific functions and how GPR43 may be modulated in the treatment of metabolic disease.
摘要
GPR43 是短链脂肪酸的受体。初步数据表明，GPR43 通过包括炎症、癌变、胃肠功能和脂肪生成在内的过程，可能在调节全身健康方面发挥作用。GPR43 参与胃肠肽的分泌，胃肠肽调节食欲和胃肠蠕动。这表明 GPR43 可能在体重控制中发挥作用。此外，GPR43 调节血浆脂质谱和炎症过程，这进一步表明 GPR43 可能有能力调节代谢性疾病（如肥胖、2 型糖尿病和心血管疾病）的病因和发病机制。本综述总结了关于 GPR43 介导全身和组织特异性功能的现有证据，以及 GPR43 在代谢性疾病治疗中如何被调节。
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