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聚焦超声推动肾结石:临床前技术的综述和更新。

Focused ultrasonic propulsion of kidney stones: review and update of preclinical technology.

机构信息

1 Division of Urology, Department of Veteran Affairs Medical Center , Seattle, Washington.

出版信息

J Endourol. 2013 Oct;27(10):1183-6. doi: 10.1089/end.2013.0315. Epub 2013 Sep 14.

DOI:10.1089/end.2013.0315
PMID:23883117
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3787400/
Abstract

A noninvasive tool to reposition kidney stones could have significant impact in the management of stone disease. Our research group has developed a noninvasive transcutaneous ultrasound device. A review and update of the current status of this technology is provided. DISCUSSION OF TECHNOLOGY: Stone propulsion is achieved through short bursts of focused, ultrasonic pulses. The initial system consisted of an eight-element annular array transducer, computer, and separate ultrasound imager. In the current generation, imaging and therapy are completed with one ultrasound system and a commercial probe. This generation allows real-time ultrasound imaging, targeting, and propulsion. Safety and effectiveness for the relocation of calyceal stones have been demonstrated in the porcine model. ROLE IN ENDOUROLOGY: This technology may have applications in repositioning stones as an adjunct to lithotripsy, facilitating clearance of residual fragments after lithotripsy, expelling de novo stones, and potentially repositioning obstructing stones. Human trials are in preparation.

摘要

一种无创的肾结石定位工具可能会对结石病的治疗产生重大影响。我们的研究小组开发了一种无创经皮超声设备。本文提供了对该技术现状的回顾和更新。技术讨论:通过短时间的聚焦超声脉冲实现结石推进。最初的系统由一个八元件环形阵列换能器、计算机和独立的超声成像仪组成。在当前的一代中,成像和治疗由一个超声系统和一个商业探头完成。这一代系统允许实时超声成像、靶向和推进。在猪模型中已经证明了该技术用于重新定位肾盏结石的安全性和有效性。在腔内泌尿外科中的作用:该技术可能适用于碎石术的辅助定位,促进碎石术后残余碎片的清除,排出新形成的结石,并可能重新定位梗阻性结石。人体试验正在准备中。

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Focused ultrasonic propulsion of kidney stones: review and update of preclinical technology.聚焦超声推动肾结石:临床前技术的综述和更新。
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引用本文的文献

1
Focused Ultrasonic Propulsion of Kidney Stones.肾结石的聚焦超声推进
J Endourol B Videourol. 2013 Dec 9;27(6). doi: 10.1089/vid.2013.0057. eCollection 2013.
2
The Impact of Dust and Confinement on Fragmentation of Kidney Stones by Shockwave Lithotripsy in Tissue Phantoms.在组织模型中冲击波碎石术对肾结石碎片形成的影响:粉尘和约束的作用。
J Endourol. 2019 May;33(5):400-406. doi: 10.1089/end.2018.0516. Epub 2019 Feb 1.
3
Combined Burst Wave Lithotripsy and Ultrasonic Propulsion for Improved Urinary Stone Fragmentation.联合冲击波碎石术与超声推进以改善尿路结石破碎
J Endourol. 2018 Apr;32(4):344-349. doi: 10.1089/end.2017.0675. Epub 2018 Mar 20.
4
Characterizing the Acoustic Output of an Ultrasonic Propulsion Device for Urinary Stones.描述一种用于尿路结石的超声推进装置的声学输出特性。
IEEE Trans Ultrason Ferroelectr Freq Control. 2017 Dec;64(12):1818-1827. doi: 10.1109/TUFFC.2017.2758647. Epub 2017 Oct 2.
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Effect of Stone Size and Composition on Ultrasonic Propulsion Ex Vivo.结石大小和成分对体外超声推进的影响。
Urology. 2018 Jan;111:225-229. doi: 10.1016/j.urology.2017.09.013. Epub 2017 Sep 28.
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Phospholipid Capped Mesoporous Nanoparticles for Targeted High Intensity Focused Ultrasound Ablation.磷脂封端介孔纳米颗粒用于靶向高强度聚焦超声消融。
Adv Healthc Mater. 2017 Sep;6(18). doi: 10.1002/adhm.201700514. Epub 2017 Jul 12.
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Safety and Effectiveness of a Longer Focal Beam and Burst Duration in Ultrasonic Propulsion for Repositioning Urinary Stones and Fragments.较长聚焦波束和脉冲持续时间在超声推进中用于重新定位尿路结石和碎片的安全性和有效性。
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Evaluation of dusting versus basketing - can new technologies improve stone-free rates?粉尘化与篮筐化的评估——新技术能否提高无石率?
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本文引用的文献

1
1pPAb5. Acoustic radiation force to reposition kidney stones.1pPAb5. 用于重新定位肾结石的声辐射力。
Proc Meet Acoust. 2013;19. doi: 10.1121/1.4799599.
2
Focused ultrasound to expel calculi from the kidney: safety and efficacy of a clinical prototype device.聚焦超声排肾结石:临床原型设备的安全性和有效性。
J Urol. 2013 Sep;190(3):1090-5. doi: 10.1016/j.juro.2013.03.120. Epub 2013 Apr 9.
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Determining a performance envelope for capture of kidney stones functionalized with superparamagnetic microparticles.确定功能化超顺磁微粒子的肾结石捕获性能范围。
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Flexible ureterorenoscopy versus extracorporeal shock wave lithotripsy for treatment of lower pole stones of 10-20 mm.输尿管软镜与体外冲击波碎石术治疗 10-20mm 下极结石的比较。
BJU Int. 2012 Sep;110(6):898-902. doi: 10.1111/j.1464-410X.2012.10961.x. Epub 2012 Feb 28.
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Focused ultrasound to expel calculi from the kidney.聚焦超声从肾脏中排出结石。
J Urol. 2012 Feb;187(2):739-43. doi: 10.1016/j.juro.2011.09.144. Epub 2011 Dec 16.
6
Limitations of ultrasonography in the evaluation of urolithiasis: a correlation with computed tomography.超声检查在评估尿路结石中的局限性:与计算机断层扫描的相关性。
J Endourol. 2012 Mar;26(3):209-13. doi: 10.1089/end.2011.0177. Epub 2011 Oct 19.
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Outcomes of long-term follow-up of patients with conservative management of asymptomatic renal calculi.无症状肾结石保守治疗患者的长期随访结果。
BJU Int. 2012 Feb;109(4):622-5. doi: 10.1111/j.1464-410X.2011.10329.x. Epub 2011 Aug 18.
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Clinically insignificant residual fragments after percutaneous nephrolithotomy: medium-term follow-up.经皮肾镜碎石取石术后残留的临床无意义碎片:中期随访。
J Endourol. 2011 Jun;25(6):941-5. doi: 10.1089/end.2010.0491. Epub 2011 May 20.
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The natural history of renal stone fragments following ureteroscopy.输尿管镜术后肾结石碎片的自然史。
Urology. 2011 Mar;77(3):564-8. doi: 10.1016/j.urology.2010.06.056. Epub 2010 Dec 15.
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Novel ultrasound method to reposition kidney stones.用于重新定位肾结石的新型超声方法。
Urol Res. 2010 Dec;38(6):491-5. doi: 10.1007/s00240-010-0319-9. Epub 2010 Oct 22.